We also think this approach is not only simpler in terms of logistics, but will also probably lead to more effective treatments, as weight or height based dosing tends to underdose. The safety of ivermectin has been proven at over >600µg/kg while the usual treatment aims to reach 200µg/kg.
We also think this approach is not only simpler in terms of logistics, but will also probably lead to more effective treatments, as weight or height based dosing tends to underdose. The safety of ivermectin has been proven at over >600µg/kg while the usual treatment aims to reach 200µg/kg.
Also important is that the combination of albendazole and ivermectin allows to treat, simultaneously, the 5 species of helminths considered by WHO as STH. Albendazole is quite effective against three of these species, but only moderately effective against a fourth (Trichuris trichiura), and very inefective (as a 400mg monotherapy) for the fifth (Strongyloides stercoralis). Treating with both medicines at once is more effective against all five, and dramatically increases the effectiveness against T trichiura and S Stercoralis. Being able to do so with a single pill, instead of 3, 4 or even more, as is common now, also drastically simplifies logistics of the MDA campaigns.
Also important is that the combination of albendazole and ivermectin allows to treat, simultaneously, the 5 species of helminths considered by WHO as STH. Albendazole is quite effective against three of these species, but only moderately effective against a fourth (Trichuris trichiura), and very inefective (as a 400mg monotherapy) for the fifth (Strongyloides stercoralis). Treating with both medicines at once is more effective against all five, and dramatically increases the effectiveness against T trichiura and S Stercoralis. Being able to do so with a single pill, instead of 3, 4 or even more, as is common now, also drastically simplifies logistics of the MDA campaigns.
The clinical trial we're supporting was a phase II/III pivotal clinical trial done in Ethiopia, Mozambique and Kenya, and has gathered enough evidence to support sending the medicine to regulatory agencies like the European Medicines Agency (EMA) and Ghana FDA.
The clinical trial we're supporting was a phase II/III pivotal clinical trial done in Ethiopia, Mozambique and Kenya, and has gathered enough evidence to support sending the medicine to regulatory agencies like the European Medicines Agency (EMA) and Ghana FDA.
We would also like to
We would also like to imply, though softly, that this medicine could also potentially be used and be of help to treat other NTDs like scabies or lymphatic filariasis.
borja
2 months ago